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Russ College of Engineering and Technology
Stocker Center
Athens, OH 45701

Douglas Goetz

Douglas Goetz
Professor, Chemical and Biomolecular Engineering
Stocker Center 163
Engineering
Biomedical Engineering
Chemical and Biomolecular Engineering
Nanoscale Quantum Phenomena Institute (NQPI)
goetzd@ohio.edu
740.593.1494

Before joining 51社区 in 1999, Dr. Goetz taught biomedical engineering at the University of Memphis. He served as a post-doctoral research fellow at Harvard Medical School and Brigham and Women's Hospital in Boston, and as a process engineer with Eli Lilly and Company.

Research Interests: Biomedical Engineering, Drug Delivery, Cell Adhesion, Biochemistry

All Degrees Earned: Ph.D. Cornell University

Journal Article, Academic Journal (58)

  • McCall, K., Walter, D., Patton, A., Thuma, J., Courreges de Benencia, M., Palczewski, G., Goetz, D., Bergmeier, S., Schwartz, F. (2023). Anti-Inflammatory and Therapeutic Effects of a Novel Small-Molecule Inhibitor of Inflammation in a Male C57BL/6J Mouse Model of Obesity-Induced NAFLD/MAFLD. 16. Journal of Inflammation Research; 2023: 5339-5366.
  • Ghazanfari, D., Courreges de Benencia, M., Belinski, L., Lloyd, J., Bergmeier, S., McCall, K., Goetz, D. (2022). Mechanistic Insights into SARS-CoV-2 Spike Protein Induction of the Chemokine CXCL10. Submitted.
  • Ghazanfari, D., Courreges, M., Belinski, L., Bergmeier, S., McCall, K., Goetz, D. (2022). Evidence for investigating GSK-3 inhibitors as potential therapeutics for severe COVID-19. Biochemical and Biophysical Research Communications; 605: 171-176.
  • Ghazanfari, D., Noori, M., Bergmeier, S., Hines, J., McCall, K., Goetz, D. (2021). A novel GSK-3 inhibitor binds to GSK-3尾 via a reversible, time and Cys-199-dependent mechanism.. Bioorganic & medicinal chemistry; 40: 116179.
  • Kauffman, M., Allen, A., Reynolds, N., Ghazanfari, D., Nazemidashtarjandi, S., Faik, A., Burdick, M., McCall, K., Goetz, D. (2020). Evidence that Knock Down of GSK-3b in Haploid Chronic Myelogenous Leukemia Cells Augments IFN-g Induced Apoptosis and Necrosis. Leukemia Research.
  • Kauffman, M., Nazemidashtarjandi, S., Ghazanfari, D., Allen, A., Reynolds, N., Faik, A., Burdick, M., McCall, K., Goetz, D. (2020). Evidence that knock down of GSK-3尾 in Chronic Myelogenous Leukemia cells augments IFN-纬-induced apoptosis.. Leukemia Research; 99: 106464.
  • Noori, M., Courreges, M., Bergmeier, S., McCall, K., Goetz, D. (2020). Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor.. European Journal of Pharmacology; 883: 173340.
  • Noori, M., Bodle, S., Showalter, C., Streator, E., Drozek, D., Burdick, M., Goetz, D. (2020). Sticking to the Problem: Engineering Adhesion in Molecular Endoscopic Imaging.. 2. Cellular and molecular bioengineering; 13: 113-124.
  • Noori, M., Bhatt, P., Courreges, M., Ghazanfari, D., Cuckler, C., Orac, C., McMills, M., Schwartz, F., Deosarkar, S., Bergmeier, S., McCall, K., Goetz, D. (2019). Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3. Am J Physiol - Cell Physiol; 317: C1289-C1303.
  • Martin, E., Malgor, R., Resto, V., Goetz, D., Burdick, M. (2019). Dynamic biochemical tissue analysis detects functional selectin ligands on cancer tissues. 1. 9: 8511. .
  • Noori, M., Streator, E., Carlson, G., Drozek, D., Burdick, M., Goetz, D. (2018). An adhesion based approach for the detection of esophageal cancer.. 12. Integrative Biology; 10: 747-757.
  • Patton, A., Church, T., Wilson, C., Thuma, J., Goetz, D., Berryman, D., List, E., Schwartz, F., McCall, K. (2018). Phenylmethimazole abrogates diet-induced inflammation, glucose intolerance and NAFLD.. 3. The Journal of endocrinology; 237: 337-351.
  • Noori, M., O'Brien, J., Champa, Z., Deosarkar, S., Lanier, O., Qi, C., Burdick, M., Schwartz, F., Bergmeier, S., McCall, K., Goetz, D. (2017). Phenylmethimazole and a Thiazole Derivative of Phenylmethimazole Inhibit IL-6 Expression by Triple Negative Breast Cancer Cells. European Journal of Pharmacology; 803: 130-137. .
  • Carlson, G., Martin, E., Shirure, V., Malgor, R., Resto, V., Goetz, D., Burdick, M. (2017). Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues. 3. PLoS ONE; 12: e0173747. .
  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. (2015). Simple Modifications to Methimazole that Enhance its Inhibitory Effect on Tumor Necrosis Factor-alpha-Induced Vascular Cell Adhesion Molecule-1 Expression by Human Endothelial Cells. European Journal of Pharmacology; 751: 59-66.
  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. (2015). Simple modifications to methimazole that enhance its inhibitory effect on tumor necrosis factor-伪-induced vascular cell adhesion molecule-1 expression by human endothelial cells.. European journal of pharmacology; 751: 59-66.
  • Shirure, V., Liu, T., Delgadillo, L., Cuckler, C., Tees, D., Benencia, F., Goetz, D., Burdick, M. (2015). CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions. 1. American Journal of Physiology-Cell Physiology; 308: C68-78.
  • Malgor, R., Bhatt, P., Connelly, B., Jacoby, D., Feldman, K., Silver, M., Nakazawa, M., McCall, K., Goetz, D. (2014). Wnt5a, TLR2 and TLR4 are Elevated in Advanced Human Atherosclerotic Lesions. Inflammation Research; 63: 277-285.
  • Deosarkar, S., Bhatt, P., Gillespie, J., Goetz, D., McCall, K. (2014). Inhibition of LPS-induced TLR4 signaling products in murine macrophages by phenylmethimazole: an assay methodology for screening potential phenylmethimazole analogs.. 8. Drug development research; 75: 497-509.
  • Malgor, R., Bhatt, P., Connolly, B., Jacoby, D., Feldmann, K., Silver, M., Nakazawa, M., McCall, K., Goetz, D. (2014). Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions.. 4. Inflammation research : official journal of the European Histamine Research Society ... [et al.]; 63: 277-85.
  • Courreges, M., Kantake, N., Goetz, D., Schwartz, F., McCall, K. (2012). Phenylmethimazole blocks dsRNA-induced IRF3 nuclear translocation and homodimerization.. 10. Molecules (Basel, Switzerland); 17: 12365-77.
  • Burdick, M., Henson, K., Delgadillo, L., Choi, Y., Goetz, D., Tees, D., Benencia, F. (2012). Expression of E-selectin ligands on circulating tumor cells: Cross-regulation with cancer stem cell regulatory pathways?. Frontiers In Oncology; 2: 103 (11 pages).
  • Kummitha, C., Shirure, V., Delgadillo, L., Deosarkar, S., Tees, D., Burdick, M., Goetz, D. (2012). HECA-452 is a Non-Function Blocking Antibody for Sialyl Lewis-x Microsphere Adhesion to Endothelial Expressed E-selectin Under Flow Conditions. 1-2. Journal of Immunological Methods; 384: 43-50.
  • Bhatt, P., Lewis, C., House, D., Keller, C., Kohn, L., Silver, M., McCall, K., Goetz, D., Malgor, R. (2012). Increased Wnt5a mRNA Expression in Advanced Atherosclerotic Lesions, and Oxidized LDL Treated Human Monocyte-Derived Macrophages.. The open circulation & vascular journal; 5: 1-7.
  • Deosarkar, S., Bhatt, P., Lewis, C., Goetz, D. (2011). Detection of Inflamed Endothelial Cells in Whole Blood Using Quantitative Real-Time PCR: A Potential Diagnostic/Prognostic Assay for Atherosclerosis.. 10. Annals of Biomedical Engineering; 39: 2627-2636.
  • Bhatt, P., Lewis, C., House, D., Goetz, D., Malgor, R. (2011). Oxidized LDL increases Wnt5a mRNA expression in human monocyte-derived macrophages.
  • Narayanaswamy, N., Faik, A., Goetz, D., Gu, T. (2011). Supercritical Carbon Dioxide Pretreatment of Corn Stover and Switchgrass for Lignocellulosic Ethanol Production. Bioresource Technology; 102: 6995-7000. .
  • Kummitha, C., Mayle, K., Christman, M., Deosarkar, S., Schwartz, A., McCall, K., Kohn, L., Malgor, R., Goetz, D. (2010). A sandwich ELISA for the Detection of Wnt5a. 1-2. Journal of Immunological Methods; 352: 38-44.
  • Benavides, U., Gonzalez-Murguiondo, M., Harii, N., Lewis, C., Sakhalkar, H., Deosarkar, S., Kurjiaka, D., Dagia, N., Goetz, D., Kohn, L. (2010). Phenyl methimazole suppresses dextran sulfate sodium-induced murine colitis. 1. European Journal of Pharmacology; 643: 129-138.
  • Kummitha, C., Mayle, K., Christman, 2nd, M., Deosarkar, S., Schwartz, A., McCall, K., Kohn, L., Malgor, R., Goetz, D. (2010). A sandwich ELISA for the detection of Wnt5a.. 1-2. Journal of immunological methods; 352: 38-44.
  • Schwartz, A., Malgor, R., Dickerson, E., Weeraratna, A., Slominski, A., Wortsman, J., Harii, N., Kohn, A., Moon, R., Schwartz, F., Goetz, D., Kohn, L., McCall, K. (2009). Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration.. 12. Clinical cancer research : an official journal of the American Association for Cancer Research; 15: 4114-22.
  • Sundd, P., Zou, X., Goetz, D., Tees, D. (2008). Leukocyte Adhesion in Capillary-Sized, P-selectin Coated Micropipettes. 2. Microcir.; 15: 109-22.
  • Deosarkar, S., Malgor, R., Fu, J., Kohn, L., Hanes, J., Goetz, D. (2008). Polymeric Particles Conjugated with a Ligand to VCAM-1 Exhibit Selective, Avid and Focal Adhesion to Sites of Atherosclerosis. 2. Biotech. and Bioeng.; 101: 400-7.
  • Christman, 2nd, M., Goetz, D., Dickerson, E., McCall, K., Lewis, C., Benencia, F., Silver, M., Kohn, L., Malgor, R. (2008). Wnt5a is expressed in murine and human atherosclerotic lesions.. 6. American journal of physiology. Heart and circulatory physiology; 294: H2864-70.
  • Hamm, A., Goetz, D., Klibanov, A., Lawrence, M. (2007). Microparticle Adhesive Dynamics and Rolling Mediated by Selectin Specific Antibodies under Flow. 3. Biotech. and Bioeng.; 96: 596-607.
  • Sakhalkar, H., Hanes, J., Fu, J., Benavides, U., Malgor, R., Borruso, C., Kohn, L., Kurjiaka, D., Goetz, D. (2005). Enhanced Adhesion of Ligand-Conjugated Biodegradable Particles to Colitic Venules. FASEB J.; 19: 792-794.
  • Zou, X., Shinde Patil, V., Dagia, N., Smith, L., Wargo, M., Interliggi, K., Lloyd, C., Tees, D., Walcheck, B., Lawrence, M., Goetz, D. (2005). PSGL-1 Derived from Human Neutrophils is a High Efficiency Ligand for Endothelial Expressed E-selectin under Flow. Am. J. Phys. 鈥 Cell Phys.; 289: C415-424.
  • Yuan, H., Goetz, D., Gaber, M., Issekutz, A., Merchant, T., Kiani, M. (2005). Radiation-Induced Up-regulation of Adhesion Molecules in Brain Microvasculature and their Modulation by Dexamethasone. Radiat Res.; 163: 544-51.
  • Harii, N., Lewis, C., Vasko, V., McCall, K., Benavides-Peralta, U., Ringel, M., Saji, M., Giuliani, C., Napolitano, G., Goetz, D., Kohn, L. (2005). Thyrocytes Express a Functional Toll-like receptor 3 (TLR3): Overexpression Can Be Induced by Viral Infection, Reversed by Pheylmethimazole, and Is Associated with Hashimoto鈥檚 Autoimmune Thyroiditis. Mol. Endo.; 19: 1231-1250.
  • Kohn, L., Schwartz, F., Silver, M., Goetz, D. (2005). Toll-like Receptors in Nonimmune Cells and Environmental Induction of the Pathologic Expression of Innate Immunity and Autoimmune Inflammatory Diseases: A New Therapeutic Opportunity. Spring; 3-11.
  • Yun, Y., Goetz, D., Yellen, P., Chen, W. (2004). Hyaluronan Microspheres for Sustained Gene Delivery and Site Specific Targeting. Biomaterials; 25: 147-157.
  • Dagia, N., Harii, N., Meli, A., Sun, X., Lewis, C., Kohn, L., Goetz, D. (2004). Phenyl Methimazole Inhibits TNF-伪-Induced VCAM-1 Expression in an IFN Regulatory Factor-1-Dependent Manner and Reduces Monocytic Cell Adhesion to Endothelial Cells. J. Immunol.; 173: 2041-2049.
  • Dagia, N., Goetz, D. (2003). A Proteasome Inhibitor Reduces Concurrent, Sequential and Long-term IL-1飦 and TNF-伪-induced ECAM Expression and Adhesion. Am J. Physiol.; 285: C813-C822.
  • Tees, D., Goetz, D. (2003). Leukocyte Adhesion: An Exquisite Balance of Hydrodynamic and Molecular Forces. News in Physiological Sciences; 18: 186-190.
  • Kiani, M., Yuan, H., Chen, X., Smith, L., Gaber, M., Goetz, D. (2002). Targeting Microparticles to Select Tissues via Radiation-Induced Upregulation of Endothelial Cell Adhesion Molecules. Pharm. Res.; 19: 1317-1322.
  • Burch, E., Shinde Patil, V., Camphausen, R., Kiani, M., Goetz, D. (2002). The N-terminal Peptide of PSGL-1 Can Mediate Adhesion to Trauma-Activated Endothelium via P-selectin in Vivo. Blood; 100: 531-538.
  • Prabhakarpandian, B., Goetz, D., Swerlick, R., Chen, X., Kiani, M. (2001). Expression and Functional Significance of Adhesion Molecules on Cultured Endothelial Cells in Response to Ionizing Radiation. 5. Microcirc.; 8: 355-364.
  • Blackwell, J., Dagia, N., Dickerson, J., Berg, E., Goetz, D. (2001). Ligand Coated Nanosphere Adhesion to E- and P-selectin under Static and Flow Conditions. 6. Annals of Biomedical Engineering; 29: 523-533.
  • Dickerson, J., Blackwell, J., Ou, J., Shinde Patil, V., Goetz, D. (2001). Limited Adhesion of Biodegradable Microspheres to E- and P-selectin under Flow. Biotechnology and Bioengineering; 73: 500-509.
  • Shinde Patil, V., Campbell, C., Yuan, Y., Slack, S., Goetz, D. (2001). Particle Diameter Influences Adhesion Under Flow. Biophys J.; 80: 1733-1743.
  • Crutchfield, K., Shinde Patil, V., Campbell, C., Parkos, C., Allport, J., Goetz, D. (2000). CD11b/CD18-coated microspheres attach to E-selectin under Flow. J. Leuk. Biol.; 67: 196-205.
  • Lim, Y., Wakelin, M., Henault, L., Goetz, D., Yednock, T., Cabanas, C., Sanchez-Madrid, F., Lichtman, A., Luscinskas, F. (2000). 飦4飦1 Integrin Activation is Necessary for High Efficiency T Cell Subset Interactions with VCAM-1 under Flow. Microcirc.; 7: 201-214.
  • Goetz, D., Greif, D., Ding, H., Camphausen, R., Howes, S., Comess, K., Snapp, K., Kansas, G., Luscinskas, F. (1997). Isolated P-selectin Glycoprotein Ligand-1 Dynamic Adhesion to P- and E-selectin. J. Cell Biol.; 137: 509-519.
  • Goetz, D., Ding, H., Atkinson, W., Vachino, G., Camphausen, R., Cumming, D., Luscinskas, F. (1996). A Human Colon Carcinoma Cell Line Exhibits Adhesive Interactions with P-selectin under Fluid Flow via a PSGL-1 Independent Mechanism. Am. J. Path; 149: 1661-1673.
  • Goetz, D., Brandley, B., Hammer, D. (1996). An E-selectin-IgG Chimera Supports Sialylated Moiety Dependent Adhesion of Human Carcinoma Cells under Fluid Flow. Annals of Biomed. Eng.; 24: 87-98.
  • Goetz, D., El-Sabban, M., Hammer, D., Pauli, B. (1996). Lu-ECAM-1 Mediated Adhesion of Melanoma Cells to Endothelium under Conditions of Flow. Int. J. Cancer; 65: 192-199.
  • Brunk, D., Goetz, D., Hammer, D. (1996). Sialyl-Lewisx/E-selectin-Mediated Rolling in a Cell-Free System. Biophys. J.; 71: 2902-2908.
  • Goetz, D., El-Sabban, M., Pauli, B., Hammer, D. (1994). Dynamics of Neutrophil Rolling Over Stimulated Endothelium in Vitro. Biophys. J.; 66: 2202-2209.

Patent (15)

  • Goetz, D., Begmeier, S., McMills, M., Orac, C. Imidazole and thiazole compositions for modifying biological signaling . 10,633,377.
  • Goetz, D., Bergmeier, S., McMills, M., Orac, C. Imidazole and thiazole compositions for modifying biological signaling -B. 10,407,420.
  • McCall, K., Schwartz, F., Goetz, D. Prevention and treatment of non-alcoholic fatty liver disease (new compounds). 10,392,381.
  • Goetz, D., Bergmeier, S., McMills, M., Orac, C. Imidazole and thiazole compositions for modifying biological signaling - C . Application # 20200017489.
  • McMills, M., Goetz, D., Bergmeier, S., Orac, C. Imidazole and Thiazole Compositions for Modifying Biological Signaling . 10,023,567.
  • McCall, K., Schwartz, F., Goetz, D., Malgor, R. Prevention and treatment of non-alcoholic fatty liver disease . 9,750,723.
  • Kohn, L., Harri, N., Benavides-Peralta, U., Gonzalez-Murguiondo, M., Lewis, C., Goetz, D., Napolitano, G., Giuliani, C., Malgor, R., Schwartz, F., McCall, K. Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression. 9,326,972.
  • Kohn, L., Harri, N., Benavides-Peralta, U., Gonzalez-Murguiondo, M., Lewis, C., Goetz, D., Napolitano, G., Giuliani, C., Malgor, R., Schwartz, F., McCall, K. Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression (Broadens 9,326972).
  • Goetz, D., McCall, K., Bergmeier, S., Schwartz, F., Bhatt, P., Deosarkar, S. Methods and compositions to modify GSK-3 activity.
  • Bergmeier, S., Goetz, D., McMall, K. A method to modify the activity of GSK-3.
  • Bergmeier, S., Goetz, D., McMall, K. Use of phenylmethyimazole for the prevention and treatment of fatty liver disease.
  • Bergmeier, S., Goetz, D., McMills, M., McMall, K. Compositions that modify biological signaling.
  • Burdick, M., Goetz, D., Malgor, R., Shirure, V., Resto, V. Dynamic biochemical tissue analysis. WO/2013/006405 .
  • Kohn, L., Goetz, D., Benavides-Peralta, U., Gonzalez-Murguiondo, M., Harii, N., Lewis, C., Napolitano, G., Dagia, N. Methods for the Amelioration of Episodes of Acute and Chronic Ulcerative Colitis. 7,928,132.
  • Goetz, D., Kiani, M. Targeting drug/gene carriers to irradiated tissue. 7,182,933.

Book, Chapter in Scholarly Book (3)

  • Tees, D., Sundd, P., Goetz, D. (2006). "A Flow Chamber for Capillary Networks: Leukocyte Adhesion in Capillary-Sized Ligand-Coated Micropipettes" in Principles of Cellular Engineering: Understanding the Biomolecular Interface. New York: M.R. King; 213-231.
  • Goetz, D., Greif, D., Shen, J., Luscinskas, F. (1999). "Cell-Cell Adhesive Interactions in an In Vitro Flow Chamber" in Adhesion Protein Protocols. Humana Press; 137-145.
  • Hammer, D., Tempelman, L., Goetz, D. (1994). "Kinetics and Mechanics of Cell Adhesion under Hydrodynamic Flow: Two Cell Systems" in Cellular Mechanics and Cellular Engineering. New York: Springer-Verlag Inc.; 121-144.

Conference Proceeding (6)

  • Bhatt, P., Lewis, C., House, D., Goetz, D., Malgor, R. (2010). Upregulation of Wnt5a transcripts in human monocytes treated with ox-LDL. Conference abstracts for the 2010 Biomedical Engineering Society Annual Meeting.
  • Malgor, R., Lewis, C., Keller, C., Kohn, L., Silver, M., Goetz, D. (2010). Wnt5a expression in human atherosclerotic plaques is elevated in macrophage-rich and complicated plaques. 2. ATHEROSCLEROSIS SUPPLEMENTS; 11: 135-135.
  • Tees, D., Sundd, P., Choi, Y., Goetz, D., Pai, A., Rogers, S. (2010). Neutrophil motion, adhesion and activation in an in vitro micropipette model of a lung capillary. Proceedings of the 3rd Joint US-European Fluids Engineering Summer Meeting and 8th International Conference on Nanochannels, Microchannels and Minichannels, August 1-5, 2010, Montreal, Canada: American Society of Mechanical Engineers; FEDSM-ICNMM2010-30177: 1-11.
  • Sakhalkar, H., Dalal, M., Salem, A., Ansari, R., Fu, J., Kiani, M., Kurjiaka, D., Hanes, J., Shakesheff, K., Goetz, D. (2003). Leukocyte-Inspired Biodegradable Particles that Selectively and Avidly Adhere to Inflamed Endothelium In Vitro and In Vivo. Proceedings of the National Academy of Sciences; 100: 15985-15900.
  • Young, V., Ridgway, D., Prudich, M., Goetz, D., Stuart, B. (2001). Criterion-Based Grading for Learing and Assessment in Unit Operations Laboratory. Albuquerque, NM: 2001 ASEE Annual Conference.
  • Young, V., Ridgway, D., Prudich, M., Goetz, D., Stuart, B. (2001). Criterion-Based Grading for Learning and Assessment in Unit Operations Laboratory. Albuquerque, NM: Session 3213, American Society for Engineering Education 2001 National Meeting.